Aggravated Cardiac Remodeling post Aortocaval Fistula in Unilateral Nephrectomized Rats

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Aggravated Cardiac Remodeling post Aortocaval Fistula in Unilateral Nephrectomized Rats.

BACKGROUND Aortocaval fistula (AV) in rat is a unique model of volume-overload congestive heart failure and cardiac hypertrophy. Living donor kidney transplantation is regarded as beneficial to allograft recipients and not particularly detrimental to the donors. Impact of AV on animals with mild renal dysfunction is not fully understood. In this study, we explored the effects of AV in unilatera...

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Impact of aortocaval shunt flow on cardiac and renal function in unilateral nephrectomized rats

We previously reported significantly enhanced cardiac remodeling post aortocaval fistula (AV) in unilateral nephrectomized (UNX) rats. However, the relationship between the size of the AV and the cardiorenal effects in UNX rats remains unknown. In the present study, AV was induced by 20, 18 and 16 gauge needles in UNX rats to see if larger shunt would definitely induce heavier cardiac and renal...

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Aortocaval Fistula

A 77-year-old Caucasian male with a history of hypertension presented with sudden onset of lower back pain, nausea, and vomiting. Initial vital signs included a pulse rate of 104 beats/minute, a blood pressure of 117/72 mm Hg, and pulse oximetry of 95% on room air. Abdominal examination revealed a midline pulsatile mass and bruit. The patient had bilateral lower extremity edema, which was worse...

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Cardiac Myocyte Size in Rats With Aortocaval Fistulas

The effects of a large arteriovenous fistula on left and right ventricular hemodynamics and cardiac myocyte size were examined in adult rats at 1 week and 1 month after surgery. Cardiac output, left ventricular function, and right ventricular function were evaluated before obtaining isolated myocytes for cell size measurements. Average heart weight increased 35% at 1 week and 86% at 1 month in ...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2015

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0134579